Artemis III will be one of the most complex undertakings of engineering and human ingenuity in the history of deep space exploration, exploring the lunar South Pole region. Artemis III will build on the crewed Artemis II flight test, adding new capabilities with the human landing system and advanced spacesuits to send the first humans to explore the lunar South Pole region. Artemis III will be one of the most complex undertakings of engineering and human ingenuity in the history of deep space exploration, exploring the lunar South Pole region. The astronauts’ observations, samples, and data collected will expand our understanding of our solar system and home planet, while inspiring the Artemis Generation.